The itinerary lasts 20hrs 48min, and has 5 steps, and it will cost 71 euros minimum.

Dublin - Holyhead
The step from Dublin to Holyhead lasts 3hrs 15min. You'll travel in a ferry.
On board, you'll have access to: Drinks and snacks, Bike.
You can find tickets from 44 euros if you book 2 months in advance.

Holyhead - London
The step from Holyhead to London lasts 3hrs 50min. You'll travel in a train longue distance from the company Avanti West Coast.
On board, you'll have access to: Wi-Fi, Drinks and snacks, Bike.
You can find tickets from 27 euros if you book 2 months in advance.

London - Brussels
The step from London to Brussels lasts 1hrs 53min. You'll travel in a high-speed train.

Brussels - Francfort
The step from Brussels to Francfort lasts 3hrs 06min. You'll travel in a high-speed train.

Francfort - Prague
The step from Francfort to Prague lasts 8hrs 44min. You'll travel in a night train.